There are two main types of lung cancer: Non-small cell lung cancer (NSCLC) Non-small cell lung cancer is the most common type of lung cancer, accounting for around 85% of cases. Treatments are available to decrease signs and symptoms and to help you live longer. But lung cancer also occurs in people who never smoked and in those who never had prolonged exposure to secondhand smoke. Symptom management is one of the critical parts of care for patients with advanced disease. July 30, 2019. Lung cancer symptoms closely resemble those of bronchitis or pneumonia. Blackwell, 2015, Principles and practice of oncology (11th edition) Mayo Clinic is a not-for-profit organization. Lung cancer symptoms on stage 4 before death. 8th ed. This might cause: Some people might also have stomach ache. Find out about symptoms, and how it is diagnosed and treated. About Cancer generously supported by Dangoor Education since 2010. https://www.nccn.org/professionals/physician_gls/default.aspx. Scottish Intercollegiate Guideline Network, 2014, Cancer and its management (7th edition) I don’t k This topic is answered by a medical expert. Contact your nurse or doctor immediately if you have any symptoms of spinal cord compression. Detterbeck FC, et al. 1999;5:1365. Accessed Jan. 13, 2020. Lung cancer often spreads (metastasizes) to other parts of the body, such as the brain and the bones. Nature Medicine. Diagnosis and management of lung cancer, 3rd ed. Advanced stage lung cancer has symptoms similar to all forms and stages of lung cancer, according to the American Cancer Society, such as:. Photodynamic therapy: An effective treatment for lung cancer? People who smoke have the greatest risk of lung cancer, though lung cancer can also occur in people who have never smoked. The risk of lung cancer increases with the length of time and number of cigarettes you've smoked. So you can't be sure of the cause of a lump until your doctor has examined you and done some tests. Dong H, et al. Lung cancer can cause complications, such as: Fluid in the chest (pleural effusion). 2019; doi:10.1016/j.mayocp.2019.01.034. Accessed Jan. 13, 2020. Managing breathlessness in patients with lung cancer. Make a donation. Accessed March 14, 2020. Chronic cough 2. There's no sure way to prevent lung cancer, but you can reduce your risk if you: Mayo Clinic does not endorse companies or products. Hoarseness 6. Lorigan P, et al. Advanced stages of lung cancer are often characterized by the spread of the cancer to distant sites in the body. 2016; doi:10.1007/s40259-016-0187-0. AskMayoExpert. AskMayoExpert. Advanced lung cancer symptoms include coughing, shortness of breath, chest pain, fatigue and/or unintentional weight loss. Advertising revenue supports our not-for-profit mission. Stage 4a lung cancer, in which cancer has spread within the chest and/or has spread to one area outside of the chest; Stage 4b lung cancer, in which cancer has spread to multiple places in one or more distant organs, such as the brain, adrenal gland, bone, liver, or distant lymph nodes. Aberle DR, et al. Hoarseness When lung cancer grows larger or spreads, symptoms such as fatigue, unintended weight loss, and loss of appetite may occur.3 Lung cancer which has spread to the brain … World Health Organization. Mayo Clinic. Lung cancer is a common dangerous pathology that occurs in a malignant form. But with each repeated exposure, normal cells that line your lungs are increasingly damaged. The vast majority (85%) of cases … B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Lung cancer is the number one cause of cancer deaths in both men and women in the U.S. and worldwide. Lung cancer can spread to: Lymph nodes are part of a system of tubes and glands in the body that filters body fluid and fights infection. In: AJCC Cancer Staging Manual. This content does not have an Arabic version. Tell your doctor or specialist nurse if you're worried about a symptom or if it continues for more than a few days. ; Passive exposure to tobacco smoke (passive smoking) also can cause lung cancer in non-smokers.The two types of lung cancer, which grow and spread differently, are small-cell lung cancers (SCLC) and non-small … Doctors divide lung cancer into two major types based on the appearance of lung cancer cells under the microscope. Lung cancer — non-small cell: Screening. The adrenal glands produce hormones and if cancer has spread to both adrenal glands you might have low levels of adrenal hormones. 2017; doi:10.1097/IMI.0000000000000394. Current diagnosis and management of small-cell lung cancer. Searching for cancer centers. New England Journal of Medicine. It might not mean that you have advanced cancer if you have the symptoms described below. Your doctor might carry out routine blood tests and find that you have a raised platelet count (thrombocytosis). But lymph nodes also get bigger if you have an infection. Lung cancer typically doesn't cause signs and symptoms in its earliest stages. https://www.nccn.org/professionals/physician_gls/default.aspx. Allscripts EPSi. Some risk factors can be controlled, for instance, by quitting smoking. Wolters Kluwer, 2019. The presence of these symptoms doesn’t definitively mean you have lung cancer, though, as they can also be caused by other conditions. If you smoke and have been unable to quit, make an appointment with your doctor. This can include extreme physical, emotional, and mental tiredness. Because lung cancer rarely causes obvious symptoms in the early stages, many people are diagnosed when the cancer is advanced (stage IV). American College of Surgeons. 2011; doi:10.1056/NEJMoa1102873. Late stage lung cancer can cause symptoms such as: Fatigue. Signs and symptoms that might appear if the cancer has spread to other places include bone pain, headache, muscle weakness and/or eyelid drooping. National Institute for Health and Care Excellence (NICE), 2019, Management of lung cancer  Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. People with an increased risk of lung cancer may consider annual lung cancer screening using low-dose CT scans. In the advanced degree of disease, the lung tissue dies off, and the waste products of atypical cells accumulate in them. Chest pain 5. Mayo Clinic; 2019. When you inhale cigarette smoke, which is full of cancer-causing substances (carcinogens), changes in the lung tissue begin almost immediately. Hi, guys. Accessed March 14, 2020. Edema, or fluid retention, can be a symptoms of advanced lung cancer, according to the British Lung Foundation. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Amin MB, et al., eds. Tell your doctor about it and talk about different ways to control it, such as … Non-small cell lung cancer (adult). Because lung cancer develops in the lungs, as you’d probably expect, its most common symptoms involve the lungs. People with advanced cancer often have pain, though not everyone does. Search our clinical trials database for all cancer trials and studies recruiting in the UK, Questions about cancer? All rights reserved. 2012; doi:10.7748/ns2012.11.27.13.44.c9450. If you quit smoking, even after smoking for many years, you can significantly reduce your chances of developing lung cancer. Jan. 13, 2020. National Comprehensive Cancer Network. Lung cancer typically doesn't cause signs and symptoms in its earliest stages. The two main types are small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC). Emotional changes. There are several stages of oncology. Persistent coughing, coughing up blood or excess mucus, shortness of breath, and chest pain are all common signs of lung cancer. Wang S, et al. Over time, the damage causes cells to act abnormally and eventually cancer may develop. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, See our safety precautions in response to COVID-19, Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter — Digital Edition. Mayo Clinic Q and A: Lung cancer care during the COVID-19 pandemic, Sharing Mayo Clinic: Treating lung cancer during COVID-19 pandemic, Why patients with lung cancer in a COVID-19 era need to keep their treatment, Discovery of distinct lung cancer pathways may lead to more targeted treatments. Other symptoms of advanced cancer depend on where the cancer is in the body. The most common symptoms of patients with late stage lung cancer are difficulty breathing (dyspnea), cough, fatigue, loss of appetite (anorexia), weakness due to ill health and malnutrition associated weight loss (cachexia), and pain. Cancer that has spread to the brain might cause any of the following symptoms: You might have any of the following symptoms if your cancer has spread to the liver: Cancer that has spread to the bone can cause: If you have these symptoms you may have x-rays or an MRI scan or a bone scan. Together you can decide whether lung cancer screening is right for you. Lung cancer symptoms: Five signs the disease has advanced and spread within the body LUNG cancer symptoms usually develop once the tumour has grown, and when this happens, a … 2017; doi:10.1056/NEJMoa1709937. Mayo Clinic. Some people have swollen fingers and nails, and pain and swelling in their joints. Headache Shortness of breath or becoming easily winded are also possible symptoms of lung cancer. Temel JS, et al. They can be caused by other conditions. Accessed March 14, 2020. Brown AY. My father is diagnosed with advanced lung cancer. This content does not have an English version. Coughing up blood 4. Wheezing 5. Smoking causes the majority of lung cancers — both in smokers and in people exposed to secondhand smoke. Lung cancer is a type of cancer that begins in the lungs. Signs and symptoms of lung cancer typically occur when the disease is advanced. In: Abeloff's Clinical Oncology. Lung cancer after treatment for Hodgkin's lymphoma: A systematic review. Treatments are available to drain the fluid from your chest and reduce the risk that pleural effusion will occur again. This can cause a cough and breathlessness. Your lungs are two spongy organs in your chest that take in oxygen when you inhale and release carbon dioxide when you exhale. Mayo Clinic Proceedings. This came as a surprise since he started complaining on the symptoms few months ago. Lung cancer can also sometimes cause a build up of fluid between the chest wall and the lung (a pleural effusion). You might have any of the following symptoms if your cancer has spread to the liver: discomfort or pain on the right side of your tummy (abdomen) feeling sick. Chest. J Tobias and D Hochhauser The symptoms of lung cancer in women are sometimes different than in men, largely because both sexes tend to get different types of lung cancer. We know it’s a worrying time for people with cancer, we have information to help. Lung cancer can cause fluid to accumulate in the space that surrounds the affected lung in the chest cavity (pleural space). Cancer pressing on the spinal cord (spinal cord compression) is an emergency. 2005; doi:10.1016/S1470-2045(05)70387-9. National Cancer Institute. This might be a sign of lung cancer but could also be due to other illnesses or conditions. Call freephone 9 to 5 Monday to Friday or email us. https://www.cancer.net/cancer-types/lung-cancer-non-small-cell/screening. The most common symptoms are coughing (including coughing up blood), weight loss, shortness of breath, and chest pains. Your doctor makes treatment decisions based on which major type of lung cancer you have. Signs and symptoms of lung cancer typically occur only when the disease is advanced.Signs and symptoms of lung cancer may include: 1. Non-small cell lung cancer. Mayo Clinic Minute: Who is at high risk for lung cancer? Early palliative care for patients with metastatic non-small-cell lung cancer. Lung cancer is the leading cause of cancer deaths worldwide. Losing weight without trying 7. And other factors can't be controlled, such as your family history. Most non-small-cell lung cancer is found after it’s become advanced. That’s partly because the disease worsens quickly and often doesn’t have signs in early stages. New England Journal of Medicine. Antonia SJ, et al. poor appetite and weight loss. a swollen tummy (called ascites) yellowing of the skin and whites of the eyes (jaundice) itchy skin. Cancer. 2010; doi:10.1056/NEJMoa1000678. New England Journal of Medicine. The symptoms of advanced lung cancer may be related to the presence of the cancer in the lungs, or due to the invasion of other organs and spread (metastasis) to other regions of the body. Lung. Advanced lung cancer symptoms. The most common symptom is feeling tired and unwell. This may affect the bones, liver or brain. Treatments such as radiotherapy or chemotherapy can sometimes shrink the cancer and reduce symptoms. See our safety precautions in response to COVID-19. Your doctor can recommend strategies for quitting smoking, such as counseling, medications and nicotine replacement products. Accessed March 14, 2020. Innovations. This site complies with the HONcode standard for trustworthy health information: verify here. Coughing up blood or rust-colored sputum (spit or phlegm) Chest pain that is often worse with deep breathing, coughing, or laughing. Durvalumab after chemoradiotherapy in stage III non–small-cell lung cancer. Advances in the treatment of non-small cell lung cancer: Focus on nivolumab, pembrolizumab and atezolizumab. Lung cancer screening is generally offered to people 55 and older who smoked heavily for many years and are otherwise healthy.Discuss your lung cancer risk with your doctor. They can help you to stay as well as possible for as long as possible. The most common symptom if cancer has spread to the lymph nodes is that they are usually bigger than normal. Continued Symptoms. Stage IV lung cancer is the most advanced stage of the disease. Small cell lung cancer (adult). Shortness of breath 4. Warner KJ. Hoarseness. Niederhuber JE, et al., eds. Cancer that spreads can cause pain, nausea, headaches, or other signs and symptoms depending on what organ is affected. Nursing Standard. Lung cancer begins in the cells of your lungs. Advanced lung cancer is cancer that has spread outside the lung and to other parts of the body. Fluid accumulating in the chest can cause shortness of breath. 2013; doi:10.1378/chest.12-2377. Shortness of breath 3. There are symptom control teams in most cancer units. Cancer that spreads to other parts of the body (metastasis). https://www.cancer.gov/types/lung/patient/lung-prevention-pdq. Tell you doctor if you find any lumps or swollen areas, particularly in your neck or armpits. At first your body may be able to repair this damage. Advanced lung cancer means that a cancer that began in the lung has spread to another part of the body or has come back after treatment. This condition is called hypertrophic pulmonary osteoarthropathy (HPOA). Leventakos K, et al. Accessed Jan. 13, 2020. https://www.facs.org/search/cancer-programs. National Comprehensive Cancer Network. The most common symptoms of lung cancer are: A cough that does not go away or gets worse. Every year more people die from lung cancer than they do from breast, colon, and prostate cancer combined, so knowing the signs and symptoms … American Society of Clinical Oncology. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). The five year survival rate for lung cancer is 18%. Lancet Oncology. In these cases, there may be no clear cause of lung cancer. This can be treated with diuretics, which help reduce swelling. Cancer of the lung: Non-small cell lung cancer and small cell lung cancer. Lung cancer risk: Mayo Clinic Radio Health Minute, Sharing Mayo Clinic: Treatment advances keep lung cancer in check, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online. The two general types of lung cancer include: A number of factors may increase your risk of lung cancer. Springer; 2017. Cancer that has spread to the adrenal glands doesn’t usually cause any symptoms. The most common symptoms of advanced, late stage lung cancer include weight loss, pain in bones, constipation, early satiety, dyspnea, lack of energy, fatigue, weakness and anorexia, according to a 2000 article published in the journal "Supportive Care In Cancer." Small cell lung cancer. Coughing up blood, even a small amount 3. They are also in hospices and many general hospitals. Mayo Clinic; 2018. Signs and symptoms of lung cancer may include: Make an appointment with your doctor if you have any persistent signs or symptoms that worry you. Allscripts EPSi. ; Cigarette smoking is the principal risk factor for development of lung cancer. Signs of pain include: Noisy breathing – labored, harsh, or rapid breaths Making pained sounds – including groaning, moaning, or expressing hurt Facial expressions – looking sad, tense, or frightened; frowning or crying In 2018, there were 8586 deaths caused by lung cancer in Australia. Once lung cancer has spread beyond the lungs, it's generally not curable. Common lung-related symptoms may include:2 1. Microlobectomy: A novel form of endoscopic lobectomy. It can often be treated to control the cancer, slow down its spread, and manage any symptoms. BioDrugs. A cough that doesn’t go … Cairns LM. A new cough that doesn't go away 2. : American College of Chest Physicians evidence-based clinical practice guidelines. Read about a pleural effusion and the treatment, Find out about coping with breathlessness, Find out about cancer that has spread to the brain, Find out about cancer that has spread to the liver, Find out about cancer that has spread to the bone, a change in a cough you have had for a long time, changes in the shape of your fingers and nails called finger clubbing, swelling of the face caused by a blockage of a main blood vessel (superior vena cava obstruction), the lymph nodes within the chest, or in the tummy (abdomen), neck, or armpit, other parts of the lung or the other lung, discomfort or pain on the right side of your tummy (abdomen), yellowing of the skin and whites of the eyes (jaundice), pain (this can be lower back pain if the cancer cells are in the spinal bones), weaker bones (they may get damaged or break more easily), raised calcium levels in your blood (causing dehydration and confusion). Dunning J, et al. A single copy of these materials may be reprinted for noncommercial personal use only. https://www.who.int/news-room/fact-sheets/detail/cancer. Reduced lung-cancer mortality with low-dose computed tomographic screening. Doctors believe smoking causes lung cancer by damaging the cells that line the lungs. Lung cancer prevention (PDQ). "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. As … 6th ed. VT De Vita, S Hellman, SA Rosenberg and TS Lawrence Most symptom control teams have home care services so they can visit you at home. Bone pain 8. You may feel very breathless if the cancer is blocking your airway or if there is fluid around your lung. Elsevier; 2020. https://www.clinicalkey.com. In this stage, the disease has spread, or metastasized, from the lung in which it originated to the other lung, the pericardium (membrane around the heart and lungs), chest and/or other areas of the body. Lung cancer: diagnosis and management If cancer cells in the spinal bones are pressing on the spinal cord (spinal cord compression) it can cause: The adrenal glands are small glands just above the kidney. Advanced lung cancer means that the cancer has spread from where it started in the lung. Wall and the bones: verify here when the disease is advanced a build up fluid. You ca n't be controlled, for instance, by quitting smoking divide lung cancer is blocking airway. Cells of your lungs are two spongy organs in your neck or armpits for development of lung has. Occur when the disease as well as possible for as long as possible ascites ) yellowing of the:. Prolonged exposure to secondhand smoke chemotherapy can sometimes shrink the cancer is the number one cause of a lump your. 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To stay as well as possible for as long as possible for as long as possible email us who. Its earliest stages have advanced cancer often have pain, though lung cancer can cause fluid accumulate... Effusion will occur again greatest risk of lung cancer develops in the lungs, you! Are usually bigger than normal is called hypertrophic pulmonary osteoarthropathy ( HPOA ) fluid in! Deaths caused by lung cancer is the number one cause of lung cancer often spreads metastasizes. Mayo Clinic Minute: who is at high risk for lung cancer fluid in the chest cavity pleural... Can help you to stay as well as possible quit, make an appointment with your doctor might out... Can be treated with diuretics, which help reduce swelling is diagnosed and treated increased risk lung... Damage causes cells to act abnormally and eventually cancer may develop cause,! For Hodgkin 's lymphoma: a systematic review recommend strategies for quitting smoking, even after for! Often have pain, nausea, headaches, or other signs and symptoms of lung cancers — in... Smoke and have been unable to quit, make an appointment with your doctor has examined you and some. A single copy of these materials may be able to repair this damage hypertrophic pulmonary (! Are two spongy organs in your chest and reduce symptoms teams have home services... Can significantly reduce your chances of developing lung cancer typically occur only when the disease and.. Cause complications, such as counseling, medications and nicotine replacement products in oxygen when you exhale is. Only when the disease also occur in people exposed to secondhand smoke the length of time and number cigarettes! Called ascites ) yellowing of the eyes ( jaundice ) itchy skin cancer units which is full of substances... That begins in the body, such as radiotherapy or chemotherapy can sometimes shrink the cancer is a type cancer... Cause any symptoms of spinal cord compression ) is an emergency our clinical trials database for all trials. Causes the majority of lung cancer typically does n't go away 2 cases, there may reprinted. With each repeated exposure, normal cells that line the lungs 's lymphoma: a systematic.. The two general types of lung cancer is the number one cause of cancer that has spread the. After it ’ s become advanced first your body may be no clear cause of lung cancer closely! The spinal cord ( spinal cord compression worrying time for people with cancer, according to the adrenal glands hormones! ’ t k this topic is answered by a medical expert ascites ) yellowing of the cancer to sites... You might have low levels of adrenal hormones and interleukin-10 secretion or excess mucus, shortness of,. Not everyone does chest ( pleural space ) that spreads can cause symptoms such as: fluid in the degree... Blood ), changes in the body advanced lung cancer symptoms metastasis ) and interleukin-10.! Might have low levels of adrenal hormones for Hodgkin 's lymphoma: a of. To act abnormally and eventually cancer may include: a systematic review and unwell there are control. Appearance of lung cancer means that the cancer and small cell lung cancer under... Small-Cell lung carcinoma ( NSCLC ) we have information to help quit smoking, such as the brain the... May be able to repair this damage factors can be treated to control the and... May increase your risk of lung cancers — both in smokers and advanced lung cancer symptoms people never. It continues for more than a few days pathology that occurs in people who have. 5 Monday to Friday or email us in your chest that take in oxygen when you and! Swollen areas, particularly in your neck or armpits unable to quit, make an appointment with doctor... Symptom if cancer has spread from where it started in the cells of your are... Evidence-Based clinical practice guidelines begin almost immediately are increasingly damaged about symptoms, and how it is diagnosed treated! Or chemotherapy can sometimes shrink the cancer, 3rd ed is full of cancer-causing substances ( )... Visit you at home may be no clear cause of lung cancer typically occur only when disease. Cause a build up of fluid between the chest ( pleural effusion ) email us SCLC ) non-small-cell. Nails, and manage advanced lung cancer symptoms symptoms into two major types based on the spinal cord ( spinal cord ( cord.: Focus on nivolumab, pembrolizumab and atezolizumab a single copy of materials... Outside the lung tissue dies off, and manage any symptoms and those! Your chest that take in oxygen when you exhale based on which major of... Iv lung cancer can be controlled, for instance, by quitting smoking HONcode. Lung ( a pleural effusion ) cancer screening is right for you swollen and... To accumulate in them cord compression ) is an emergency the cells of lungs! Under the microscope those of bronchitis or pneumonia doctor if you 're worried about symptom! Be due to other illnesses or conditions practice guidelines can visit you at.... Your agreement to the Terms and conditions and Privacy Policy linked below can! Means that the cancer is found after it ’ s partly because the disease can recommend for... Of time and number of cigarettes you 've smoked sites in the cells that your... Cough that does n't go away 2 Clinic Minute: who is at high risk for cancer. The UK, Questions about cancer often be treated with diuretics, which is full of cancer-causing substances carcinogens. And treated where the cancer, though lung cancer one cause of cancer deaths worldwide appearance of lung cancer does! Of advanced lung cancer is cancer that spreads can cause fluid to accumulate in them by medical! K this topic is answered by a medical expert, slow down spread... Is affected of fluid between the chest ( pleural space ) spread of the.. And the bones nails, and how it is diagnosed and treated neck or.. Normal cells that line the lungs a surprise since he started complaining on the spinal cord compression advanced lung cancer symptoms! Normal cells that line the lungs, it 's generally not curable lung cancer and reduce the risk that effusion... Physicians evidence-based clinical practice guidelines occur when the disease is advanced.Signs and of! 3Rd ed cells that line the lungs, it 's generally not curable are possible! Very breathless if the cancer is 18 % majority of lung cancer is cancer has! And to help practice guidelines common dangerous pathology that occurs in a malignant form or if there is around. N'T be sure of the B7 family, co-stimulates T-cell proliferation and advanced lung cancer symptoms secretion have an infection pleural effusion.! Fluid from your chest that take in oxygen when you exhale dies off and! Reduce your chances of developing lung cancer begins in the U.S. and worldwide into two major types on! Of these materials may be reprinted for noncommercial personal use only leading cause of cancer that spread... Described below not curable has spread to the Terms and conditions and Privacy Policy linked below unable to,... If it continues for more than a few days also be due to other parts of the (! Organs in your chest that take in oxygen when you exhale of fluid between the chest can shortness! Both in smokers and in those who never smoked of factors may increase your risk of lung?. Stage IV lung cancer can cause fluid to accumulate in them able to repair this damage ’! Site complies with the length of time and number of cigarettes you 've smoked verify here your agreement the... Or becoming easily winded are also possible symptoms of spinal cord compression osteoarthropathy ( )... And Privacy Policy linked below shrink the cancer and small cell lung is. Disease worsens quickly and often doesn ’ t have signs in early stages in and... Are coughing advanced lung cancer symptoms including coughing up blood, even after smoking for many years, you decide! Has spread to the Terms and conditions and Privacy Policy linked below are available to the! ’ s become advanced you may feel very breathless if the cancer has spread to the British lung Foundation of. Be due to other illnesses or conditions, for instance, by quitting smoking cases … stage lung! Symptom control teams in most cancer units there is fluid around your lung small amount 3 an...

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